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目的 研究雌激素受体 (ER)基因多态性是否与冠心病 (CHD)有相关性。方法 用聚合酶链反应 限制性酶切长度多态性分析方法 ,对 72例CHD组患者和 5 3例对照组的ER基因多态性进行分析 ,比较ER基因多态性在两组之间和在CHD组不同临床表现 (稳定性心绞痛和急性冠脉综合征 )之间分布的差异性 ,并比较 3种ER基因型与冠心病相关的临床指标。结果 PP基因型在CHD组和急性冠脉综合征组中的分布频率明显高于对照组和稳定性心绞痛组 (P <0 .0 5 )。PP基因型的高血压病患病率 6 4 .0 % ,纤维蛋白原浓度 (3.6± 0 .8)g/L ,体重指数 2 5 .4± 2 .8和高密度脂蛋白胆固醇浓度 (1.0± 0 .2 )mmol/L ,与其他基因型有显著性差异 (P <0 .0 5 )。结论 ER基因多态性可能通过改变ER的表达 ,而影响ER介导的心血管保护作用。
Objective To investigate whether estrogen receptor (ER) gene polymorphism is associated with coronary heart disease (CHD). Methods The polymerase chain reaction restriction fragment length polymorphism analysis method was used to analyze the genetic polymorphism of ER in 72 CHD patients and 53 control subjects. The polymorphism of ER gene was compared between the two groups The differences in the distribution between different clinical manifestations (stable angina and acute coronary syndrome) in the CHD group were compared with those of the three ER genotypes in relation to coronary heart disease. Results The distribution frequency of PP genotype in CHD group and acute coronary syndrome group was significantly higher than that in control group and stable angina pectoris group (P <0.05). The prevalence of hypertension with PP genotype was 64.04%, fibrinogen concentration (3.6 ± 0.8) g / L, body mass index 2.54 ± 2.8 and high density lipoprotein cholesterol concentration (1.0 ± 0.2) mmol / L, which was significantly different from other genotypes (P <0.05). Conclusion ER gene polymorphism may affect the ER-mediated cardiovascular protection by changing the expression of ER.