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1.前言近年来,随着合成化学技术及生物技术的惊人发展,已经能够生产多种廉价的氨基酸,天冬氨酸就是其中一例。天冬氨酸为具有α-手性中心的多官能团化合物,因而具有引人注目的特殊反应,是合成光学活性化合物的一个十分吸引人的原料。 2.天冬氨酸的特性和制备天冬氨酸虽然不属于人体必需氨基酸,但在三羧酸循环、鸟氨酸循环、核酸的生物合成等方面起着重要作用。 DL-天冬氨酸由富马酸或马来酸氨化制
1. Introduction In recent years, as the amazing development of synthetic chemistry technology and biotechnology has been able to produce a variety of cheap amino acids, aspartic acid is one of them. Aspartic acid is a polyfunctional compound with an a-chiral center and therefore has a remarkable and special reaction and is a very attractive starting material for the synthesis of optically active compounds. 2. Characteristics and preparation of aspartic acid Although aspartic acid does not belong to the human body essential amino acids, but plays an important role in the tricarboxylic acid cycle, ornithine cycle, nucleic acid biosynthesis and so on. DL-aspartic acid is made from amidation of fumaric acid or maleic acid