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本文介紹16个药物对家兔Brown-Pearce癌实驗治疗的結果。这16个药物是,Thio-TEPA,BCM,HN_2,MBAO,TEM,AT-16,AT-222,AT-290,AT-346,AT-581,3P,合-14,Sb-57,Sb-7l,AC-808和放线菌素K.实驗証明,氮芥类药物AT-581[邻双-(β-氯乙基)氨甲基苯丙氨酸二盐酸盐]对靜脉接种此肿瘤有明显的抑制效能。以0.7毫克/公斤靜脉注射每天1針共12天,能显著延长肿瘤家兔的平均生存时間,延长率为130％(P<0.001),对肺和肝脏的重量和轉移病灶数也有明显的抑制作用。以1毫克/公斤靜脉注射时,能使肿瘤全部抑制,肺、肝和腎脏的重量比对照組明显下降。其它15个药物的作用不显著。本文对实驗方法及疗效指标等問題也进行了討論。
This article describes the results of 16 experimental treatments of Brown-Pearce cancer in rabbits. The 16 drugs are Thio-TEPA, BCM, HN_2, MBAO, TEM, AT-16, AT- 222, AT- 290, AT- 346, AT- 581, 7l, AC-808 and actinomycin K. Experiments show that the nitrogen mustard AT-581 [o-bis- (β-chloroethyl) aminomethyl phenylalanine dihydrochloride] Obvious inhibitory potency. Intravenous injection of 0.7 mg / kg intravenously for 1 day for a total of 12 days significantly prolonged the mean survival time of tumor rabbits by 130% (P <0.001), as well as the weight of lung and liver and the number of metastatic lesions Inhibition. At 1 mg / kg intravenous injection, can make all the inhibition of the tumor, lung, liver and kidney weight than the control group decreased significantly. The effect of other 15 drugs is not significant. This article also discussed the experimental methods and efficacy indicators and other issues.