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为探讨妊高征孕妇血清、脐动脉血清中ＴＮＦ－α水平的变化，采用放射免疫法测定妊高征孕妇血清、脐动脉血清中ＴＮＦ－α的水平。其中轻度妊高征１４例，中度妊高征１１例，重度妊高征１９例，并以４４例正常足月妊娠为对照组。结果：轻度妊高征孕妇血清中ＴＮＦ－α水平已明显增高，并随病情加重有增高趋势，以重度妊高征更为明显（Ｐ＜０．０５）；中、重度妊高征脐动脉血清ＴＮＦ－α水平明显高于对照组（Ｐ＜０．０５）。妊高征发病机制可能与免疫系统失常有关，测定妊高征孕妇血清ＴＮＦ－α水平可作为判定其病情程度的一项指标。
In order to investigate the changes of serum TNF-α levels in serum and umbilical artery of pregnant women with PIH, the level of TNF-α in serum and umbilical artery of pregnant women with PIH was determined by radioimmunoassay. Fourteen cases of mild PIH, 11 cases of moderate PIH, 19 cases of severe PIH, and 44 cases of normal term pregnancy as control group. Results: The level of TNF-α in serum of pregnant women with mild PIH was significantly higher than that of normal pregnant women (P <0.05) Serum TNF-α levels were significantly higher than the control group (P <0.05). The pathogenesis of PIH may be related to the disorder of the immune system. Determining the level of serum TNF-α in pregnant women with PIH can be used as an index to determine the severity of PIH.