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目的探讨偏头痛的临床特点及与代谢综合征(metabolic syndrome,MS)的相关性。方法选取2015年2月—2016年12月就诊于本院的偏头痛患者120例进行问卷调查,记录头痛特点及合并症,利用人体测量学、血液生化明确代谢综合征的诊断,经颅多普勒超声测量颅内血管功能。计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果120例偏头痛患者中,68例(56.67%)合并一种或多种代谢异常,18例(15.0%)合并代谢综合征。头痛持续时间≥4 h患者中,合并轻度代谢异常与合并代谢综合征的比例为75.0%、66.67%,显著高于<4 h的偏头痛患者的25.0%、33.33%,差异有统计学意义(P<0.05);过度使用止痛药患者合并代谢综合征者占16.67%,合并轻度代谢异常者占13.24%,显著高于无代谢异常者的8.82%,差异有统计学意义(P<0.05)。结论偏头痛合并代谢综合征与过度使用止痛药有关,合理使用止痛药可能降低偏头痛患者发生代谢综合征及心血管疾病的风险。
Objective To investigate the clinical features of migraine and its relationship with metabolic syndrome (MS). Methods A total of 120 migraineurs treated in our hospital from February 2015 to December 2016 were surveyed to survey the characteristics of headache and comorbidities. The results of anthropometry, biochemical analysis of metabolic syndrome and transcranial Doppler Ultrasound measurement of intracranial vascular function. Count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results Among 120 migraineurs, 68 (56.67%) had one or more metabolic abnormalities and 18 (15.0%) had metabolic syndrome. The patients with headache duration≥4 h had a mild metabolic rate of 75.0% and metabolic syndrome (66.67%), which was significantly higher than 25.0% and 33.33% of those with migraine <4 h (P0.05); those with overuse of painkillers accounted for 16.67% with metabolic syndrome, those with mild metabolic abnormalities accounted for 13.24%, significantly higher than those with no metabolic abnormalities (P <0.05) ). Conclusions Migraine with metabolic syndrome is associated with overuse of painkillers, and the rational use of painkillers may reduce the risk of metabolic syndrome and cardiovascular disease in migraineurs.