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为探讨急性缺血性心力衰竭（ＨＦ）形成过程中心机械功能变化特征及其意义，观察８只家兔，于冠状动脉左室支结扎后，不同时间点的左室收缩、舒张及射血功能的变化趋势，并与７只假手术家兔比较。结果：与假手术兔比较，ＨＦ兔于拮扎后５ｍｉｎ，１５ｍｉｎ，３０ｍｉｎ，６０ｍｉｎ，１２０ｍｉｎ和１８０ｍｉｎ，左室内压上升最大速率分别降低：２２．３％，１８．３％，８．４％，７．４％，２３．８％和４１．８％（均Ｐ＜０．０５）；左室收缩峰压分别降低：２３．８％（Ｐ＜０．０５），１０．７％（Ｐ＜０．０５），６．４％，６．９％，１３．９％（Ｐ＜０．０５）和４０．８％（Ｐ＜０．０５）；左室内压下降最大速率分别降低３２．９％，２０．０％，１３．９％，１１．８％，２８．８％和４５．５％（均Ｐ＜０．０５）；左室舒张末压分别升高：３８０．０％，２５０．０％，２６０．０％，２４３．８％，７２６．７％和１４５０％（均Ｐ＜０．０５）；心输出量分别降低：０．４％，４．０％，７．４％，１２．４％（Ｐ＜０．０５），２３．４％（Ｐ＜０．０５）和３６．９％（Ｐ＜０．０５）。结果表明，心脏收缩与舒张功能于冠脉结扎后呈急剧下降－缓慢恢复－再继续下降的变化，尤以舒张功?
In order to explore the characteristics and significance of central mechanical changes in the process of acute ischemic heart failure (HF), we observed the left ventricular systolic and diastolic function and ejection function in 8 rabbits after left coronary artery ligation, at different time points The trend of change, and compared with seven sham rabbits. Results: Compared with sham-operated rabbits, the maximal rate of increase of left ventricular pressure in HF rabbits decreased by 22.3%, 18.3% and 8.4%, respectively, at 5 min, 15 min, 30 min, 60 min, 120 min and 180 min 7.4%, 23.8% and 41.8%, respectively (all P <0.05). The peak systolic pressure of left ventricle decreased 23.8% (P <0.05) and 10.7% (P < 0.05), 6.4%, 6.9%, 13.9% (P <0.05) and 40.8% (P <0.05) respectively. The maximum rate of LV pressure drop decreased by 32.9 %, 20.0%, 13.9%, 11.8%, 28.8% and 45.5% respectively (all P <0.05). Left ventricular end-diastolic pressure increased by 380.0%, 250 .0%, 260.0%, 243.8%, 726.7% and 1450% respectively (all P <0.05); the cardiac output decreased by 0.4%, 4.0%, 7.4% 12.4% (P <0.05), 23.4% (P <0.05) and 36.9% (P <0.05). The results showed that cardiac systolic and diastolic function showed a sharp decline after coronary ligation - slow recovery - and then continue to decline, especially diastolic function?