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[目的]了解和分析子宫内膜间质细胞肉瘤的特异性标志物,以其病例分析结果辅助临床正确诊断。[方法]将子宫内膜间质肉瘤24例临床资料作为实验组,并用子宫平滑肌瘤25例作为对照组,检测其雌激素受体、孕激素受体、CD10与CD44v3的表达。[结果]子宫内膜间质肉瘤中雌、孕激素受体的表达水平均显著低于子宫平滑肌瘤(P﹤0.01)。CD10与CD44v3是鉴别子宫内膜间质肉瘤与子宫平滑肌瘤的特异性标志物(P﹤0.01)。[结论]应常规检测ER与PR,CD10和CD44v3用于诊断ESS的敏感性高,可作为其辅助诊断指标。
[Objective] To understand and analyze the specific markers of endometrial stromal cell sarcoma, with the help of its case analysis to help correct the clinical diagnosis. [Method] The clinical data of 24 cases of endometrial stromal sarcoma were used as experimental group, and 25 cases of uterine leiomyoma were used as control group to detect the expression of estrogen receptor, progesterone receptor, CD10 and CD44v3. [Results] The expression levels of estrogen and progesterone receptor in endometrial stromal sarcoma were significantly lower than those in uterine leiomyoma (P <0.01). CD10 and CD44v3 are specific markers for differentiating endometrial stromal sarcoma and uterine leiomyoma (P <0.01). [Conclusion] The sensitivity of routinely detecting ER, PR, CD10 and CD44v3 in the diagnosis of ESS is high and can be used as an auxiliary diagnostic indicator.