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一氧化氮(NO)作为一种重要的信使分子和细胞毒性因子,可参与体内诸多生理活动和病理过程,如神经信息传递,血压调节,免疫防御,学习和记忆等。最近几年的研究还证明,NO对哺乳动物的生殖活动有重要的调节作用。一氧化氮合成酶(NOS)广泛存在于睾丸,附睾,输精管,前列腺,精囊腺,阴茎等生殖系统中。由其合成的NO可参与精子发生、精子成熟、精原细胞凋亡,雄激素分泌以及阳萎早泄等生殖活动的调节。NO合成不足或过量都能引起男性生育力的下降。借助生物学方法改变内源性NO的合成,将成为临床治疗相关不育的有效手段。
Nitric oxide (NO), as an important messenger molecule and cytotoxic factor, can participate in many physiological and pathological processes in the body, such as nerve information transmission, blood pressure regulation, immune defense, learning and memory. Studies in recent years have also demonstrated that NO plays an important regulatory role in mammalian reproductive activities. Nitric oxide synthase (NOS) is widespread in the testes, epididymis, vas deferens, prostate, seminal vesicles, penis and other reproductive systems. The synthesis of NO can participate in spermatogenesis, sperm maturation, spermatogonial apoptosis, androgen secretion and impotence premature ejaculation and other reproductive activities. NO synthesis or excess can cause male fertility decline. Using biological methods to change the synthesis of endogenous NO, will become an effective means of clinical treatment of infertility.