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目的 :探讨 2 1℃海水浸泡失血性休克大鼠时血液动力学的变化。方法 :采用Wister雄性大鼠 2 1只 ,随机分为平原失血性休克组 (n =10 )、海水浸泡失血性休克组 (n =11)。运用四道生理记录仪监测动物伤前及休克终点、10 ,30 ,6 0 ,180 ,30 0min时血液动力学的变化。结果 :海水浸泡动物早期血压升高 ,但很快下降 ,并且显著低于陆地失血性休克动物 ;海水浸泡失血性休克动物血液动力学显著低于陆地失血性休克组动物 ,入水30 0min时±dp/dtmax、LVSP ,HR ,MAP ,RR仅为陆地失血性休克动物的 5 9% ,5 6 .5 % ,4 1.6 % ,5 7.8% ,4 3.4 %。结论 :2 1℃海水浸泡失血性休克动物血液动力学状态明显恶化 ,动物死亡率明显增大。
Objective: To investigate the hemodynamic changes of hemorrhagic shock rats exposed to seawater at 2 ℃. Methods: Twenty-one male Wister rats were randomly divided into two groups: n = 10 in hemorrhagic shock group and n = 11 in seawater hemorrhagic shock group. The changes of hemodynamics of animals before and at the end of shock, 10, 30, 60, 180 and 300 min were monitored by using four physiological loggers. Results: In the early stage of seawater immersion animals, the blood pressure increased rapidly but decreased rapidly and was significantly lower than that of land hemorrhagic shock animals. The hemodynamics of seawater immersion hemorrhagic shock animals was significantly lower than that of land hemorrhagic shock rats, and ± dp / dtmax, LVSP, HR, MAP, RR were only 59%, 56.5%, 41.6%, 57.8% and 44.4% of those on land hemorrhagic shock animals. Conclusion: The hemodynamic status of hemorrhagic shock rats exposed to seawater immersion in seawater is obviously deteriorated, and the mortality of animals is obviously increased.