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目的寻找肝纤维化等慢性肝病敏感可靠的血清学诊断指标。方法对１９６例各型肝病联合检测血清透明质酸（ＨＡ）、脯氨酸肽酶（ＰＬＤ）、Ⅲ型前胶原（ＰＣⅢ）、层粘蛋白（ＬＮ）、ＩＶ型胶原（ＩＶ－Ｃ），并与１０例肝组织学和３０例健康献血员做对照研究。结果五项指标分别在急性肝炎、慢性肝炎和肝硬化中依次升高，差异显著（Ｐ＜００５或Ｐ＜００１），其改变情况与轻、中、重型纤维化程度呈同步性，有良好的正相关。结论五项指标联合检测可极大地增加慢性肝病临床诊断的准确性与可靠性，动态观察其变化可掌握病情演变
Objective To find a sensitive and reliable serological diagnostic index for chronic liver diseases such as liver fibrosis. Methods Serum hyaluronic acid (HA), proline peptidase (PLD), type Ⅲ procollagen (PC Ⅲ), laminin (LN), type IV collagen And compared with 10 cases of liver histology and 30 healthy blood donors. Results The five indexes increased successively in acute hepatitis, chronic hepatitis and cirrhosis, with significant difference (P <005 or P <001), and their changes were in synchronicity with the severity of mild, moderate and severe fibrosis , There is a good positive correlation. Conclusion Combined detection of five indicators can greatly increase the accuracy and reliability of clinical diagnosis of chronic liver disease, dynamic observation of its changes can grasp the evolution of the disease