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目的研究乙肝孕妇早孕期甲状腺激素分泌特点。方法应用化学发光微粒子免疫分析方法检测104例研究对象的早孕期甲状腺激素,104例研究对象分为对照组20例,为非乙肝孕妇,轻度慢性乙型肝炎组22例、中重度慢性乙型肝炎组22例、非活动性HBsAg携带组20例、慢性HBV携带组20例(HBV-DNA大于等于107拷贝/ml)。应用SPSS17.0统计软件对结果进行统计学分析。结果中重度慢性乙型肝炎组T3(1.59±0.35)、T4(10.80±1.45)、FT3(3.33±0.45)高于对照组T3(1.37±0.21)、T4(9.72±1.47)、FT3(3.08±0.21),差异有显著性意义,中重度慢性乙型肝炎组TSH(1.11±1.03)及慢性HBV携带组TSH(0.90±0.48)低于对照组TSH(2.01±1.35),差异有显著性意义,其余各组甲状腺激素与对照组相比均无显著性差异。结论中重度慢性乙型肝炎孕妇早孕期甲状腺激素水平不同于非乙肝孕妇,增强对乙肝孕妇甲状腺激素分布特点的认识,有助于更准确地诊治乙肝孕妇甲状腺功能疾病。
Objective To study the characteristics of thyroid hormone secretion in the first trimester of hepatitis B pregnant women. Methods 104 cases of thyroid hormones in early pregnancy were detected by chemiluminescence microparticle immunoassay. 104 cases were divided into control group (n = 20), pregnant women without HBV, mild chronic hepatitis B (n = 22), moderate to severe chronic type B Twenty-two hepatitis B patients, 20 non-active HBsAg carriers and 20 chronic HBV carriers (HBV-DNA greater than or equal to 107 copies / ml). SPSS 17.0 statistical software was used to analyze the results. Results Compared with control group, T3 (1.59 ± 0.35), T4 (10.80 ± 1.45), FT3 (3.33 ± 0.45) were significantly higher in moderate to severe chronic hepatitis B group than those in control group (T3.37 ± 0.21), T4 0.21 ± 0.48) were lower than that of the control group (TSH: 1.11 ± 1.03) and TSH (0.90 ± 0.48) in the chronic HBV-carrying group, the difference was statistically significant The remaining groups of thyroid hormone compared with the control group no significant difference. Conclusions The serum levels of thyroid hormone in pregnant women with moderate-severe chronic hepatitis B are different from those of non-hepatitis B pregnant women in the first trimester, and their cognition on the distribution of thyroid hormone in pregnant women with hepatitis B is enhanced. It is helpful to diagnose and treat the thyroid function diseases of pregnant women with hepatitis B more accurately.