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目的：研究老年肺癌患者雌、孕激素受体表达的临床意义。方法：用免疫组化法（ＡＢＣ法）检测２５例老年肺癌组织、６例正常肺组织、５例肺良性病变组织（对照组）纤支镜活检标本的雌激素受体（ＥＲ）和孕激素受体（ＰＲ），并试用三苯氧胺对其中１０例肺癌患者行内分泌治疗。结果：老年肺癌患者的ＥＲ阳性率为６４％（１６／２５），ＰＲ阳性率为３６％（９／２５），而对照组未发现ＥＲ和ＰＲ，且三苯氧胺对老年肺癌患者有效。结论：部分老年肺癌患者组织中存在着ＥＲ、ＰＲ，其测定为选择性应用内分泌疗法治疗肺癌提供了理论依据。
Objective: To study the clinical significance of estrogen and progesterone receptor expression in elderly patients with lung cancer. METHODS: Estrogen receptor (ER) and progesterone were detected by immunohistochemical method (ABC method) in fibrin biopsy specimens of 25 elderly lung cancer tissues, 6 normal lung tissues, and 5 benign pulmonary lesions (control group). Receptors (PR) and try tamoxifen for endocrine therapy in 10 patients with lung cancer. Results: The positive rate of ER in elderly patients with lung cancer was 64% (16/25), and the positive rate of PR was 36% (9/25). No ER and PR were found in the control group, and tamoxifen was effective in elderly patients with lung cancer. Conclusion: There are ER and PR in the tissues of some elderly patients with lung cancer. The assay provides a theoretical basis for the selective application of endocrine therapy for lung cancer.