Aiming at the disadvantages of BP model in artificial neural networks applied to intelligent fault diagnosis, neural network fault diagnosis optimization method with rough sets and genetic algorithms are presented. The neural network nodes of the input layer can be calculated and simplified through rough sets theory; The neural network nodes of the middle layer are designed through genetic algorithms training; the neural network bottom-up weights and bias are obtained finally through the combination of genetic algorithms and BP algorithms. The analysis in this paper illustrates that the optimization method can improve the performance of the neural network fault diagnosis method greatly. Aiming at the disadvantages of BP model in artificial neural networks applied to intelligent fault diagnosis, neural network fault diagnosis optimization method with rough sets and genetic algorithms are presented. The neural network nodes of the input layer can be calculated and simplified through rough sets theory; The neural network nodes of the middle layer are designed through genetic algorithms training; the neural network bottom-up weights and bias are obtained finally combining the genetic algorithms and BP algorithms. The analysis in this paper shows that the optimization method can improve the performance of the neural network fault diagnosis method greatly.