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已有证据提示花生四烯酸的代谢产物与胎儿的多种功能有关,这些功能多受局部组织所产生的前列腺素的调节。有人报告胎儿循环中也有前列腺素存在,且其浓度比母体循环中高,因此推测这些前列腺素可能对胎儿具有生理性作用。本文着重讨论了胎儿体液内的前列腺素变化,前列腺素对胎儿某些内分泌功能的影响,以及对胎儿发育的作用。一、正常胎儿和新生儿体液内的前列腺素作者研究发现胎儿不同部位(胎儿颈总动脉与股动脉)血中PGE与PGF的浓度是相关的,临出生前两者的浓度均显著升高。胎儿脐血中的PGE,PGF及前列腺素代谢物13,14-双氢-15酮-PGF_(2α)(PGFM)浓度均比母体周围血浆中高,但尚未证实脐动脉与脐静脉血中的浓度有固定的差异。分娩活跃期时,脐血内的前列腺素浓度不断增加。脐血浆内血小板凝集素B_2(thromboxane P_2)
There is evidence that arachidonic acid metabolites are associated with multiple functions of the fetus, many of which are regulated by prostaglandins produced by the local tissues. It is reported that there are prostaglandins also exist in the fetal circulation, and its concentration than the maternal cycle is high, so speculated that these prostaglandins may have physiological effects on the fetus. This article focuses on the prostaglandin changes in the fetal body fluids, the effects of prostaglandins on certain endocrine functions of the fetus, and the effects on fetal development. First, the normal fetal and neonatal body fluids prostaglandins Author study found that different parts of the fetus (fetal carotid artery and femoral artery) blood PGE and PGF concentrations are related to the concentration of the two were significantly increased. Fetal umbilical cord blood PGE, PGF and prostaglandin metabolites 13,14-dihydro-15-keto-PGF 2α (PGFM) concentrations were higher than the plasma in the maternal, but not yet confirmed umbilical artery and umbilical venous blood concentrations There are fixed differences. When labor is active, the prostaglandin concentration in umbilical cord blood continuously increases. Umbilical plasma thromboglobulin B 2 (thromboxane P 2)