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目的分析紫癜性肾炎患者的临床特征及预后,探讨影响预后的因素。方法 2004年至2009年确诊为过敏性紫癜的住院患者56例,分析其中合并肾损害32例患者的临床特征;追踪两年观察其预后。结果 56例过敏性紫癜患者中,合并肾损害者为32例,占57.1%。肾损害主要表现为血尿、非肾病范围蛋白尿、肾功能不全等。平均随访(2.05±0.26)年,3例患者出现血清肌酐增高1倍,其临床特点为首次诊断时血清肌酐水平较高、发病年龄较大、紫癜复发次数较多等。结论半数过敏性紫癜患者伴发紫癜性肾炎,后者2年内肾功能下降比率约9.4%;发病年龄较大、紫癜复发次数较多等因素是肾功能不全进展的危险因素。
Objective To analyze the clinical features and prognosis of patients with purpura nephritis and to explore the factors that affect the prognosis. Methods Fifty-six inpatients with Henoch-Schonlein purpura diagnosed from 2004 to 2009 were enrolled in this study. The clinical features of 32 patients with renal damage were analyzed. The prognosis was followed up for two years. Results 56 cases of allergic purpura patients, with renal damage were 32 cases, accounting for 57.1%. Kidney damage mainly for hematuria, non-nephrotic proteinuria range, renal insufficiency. The average follow-up (2.05 ± 0.26) years, 3 patients with serum creatinine increased 1 times, the clinical features of the first diagnosis of higher serum creatinine, age of onset, purpura recurrence frequency and more. Conclusions Half of the patients with HSP were accompanied by purpuric nephritis, the latter with a decline rate of 9.4% within 2 years. The older age of onset and the higher frequency of recurrent purpura were the risk factors for the progression of renal insufficiency.