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目的 研究ICAM - 1在慢性牙周炎牙龈组织中白细胞的表达 ,探讨ICAM - 1在慢性牙周炎免疫病因机理中和作用。方法 应用抗ICAM - 1单克隆抗体 ,通过碱性磷酸酶 -抗碱性磷酸酶的免疫组织化学技术 ,对I CAM - 1在正常和慢性牙周炎的牙龈组织中白细胞的表达进行分析。结果 ICAM - 1阳性白细胞主要聚集于慢性牙周炎结合上皮和袋上皮下方结缔组织中 ,慢性牙周炎牙龈组织单位面积中表达ICAM - 1阳性的白细胞的比例显著高于正常牙龈组 (P <0 .0 1)。结论 ICAM - 1可能参与和调节慢性牙周炎牙龈组织中白细胞介导的免疫粘附过程。
Objective To study the expression of ICAM - 1 in gingival tissues of patients with chronic periodontitis and to explore the role of ICAM - 1 in the pathogenesis of chronic periodontitis. Methods Anti - ICAM - 1 monoclonal antibody was used to analyze the expression of I CAM - 1 in gingival tissues of normal and chronic periodontitis by immunohistochemistry with alkaline phosphatase - anti - alkaline phosphatase. Results ICAM - 1 positive leukocytes mainly accumulated in connective tissues of chronic periodontitis - associated epithelium and subepithelial epithelium. The proportion of ICAM - 1 positive leukocytes per unit area of gingival tissues in chronic periodontitis was significantly higher than that in normal gingival tissues (P < 0 .0 1). Conclusion ICAM - 1 may participate in and regulate leukocyte - mediated immune adhesion in gingival tissues of chronic periodontitis.