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目的：为探讨糖尿病肾病与高血压家族史的关系。方法：采用Ｃａｎｅｓｓａ 改良法对４１ 例２型糖尿病患者测定红细胞钠－锂逆转运（ＲＢＣＳＬＣ）活力及尿白蛋白排泄率（ＵＡＥＲ）。结果：伴有高血压家族史２ 型糖尿病（ＤＨ）组的ＲＢＳＳＬＣ活力明显高于不伴高血压家族史２ 型糖尿病（ＤＮ）组和对照组，且ＤＨ 组ＵＡＥＲ均值较ＤＮ组和对照组亦显著增加，并与ＲＢＣＳＬＣ的升高相平行。结论：遗传因素对２ 型糖尿病患者ＲＢＣＳＬＣ活力有影响，ＲＢＣＳＬＣ活力增高可能是糖尿病肾病遗传易感性的一个指标
Objective: To investigate the relationship between diabetic nephropathy and family history of hypertension. Methods: Caesar ’s modified method was used to determine RBCSLC activity and urinary albumin excretion rate (UAER) in 41 patients with type 2 diabetes mellitus. Results: The activity of RBSSLC in type 2 diabetic patients with family history of hypertension was significantly higher than that in type 2 diabetic patients without family history of hypertension and control group. The mean UAER in DH group was also significantly higher than those in DN group and control group Significantly increased, and parallel with the rise of RBCSLC. CONCLUSIONS: Genetic factors have an impact on the activity of RBCSLC in type 2 diabetic patients. The increased activity of RBCSLC may be an indicator of genetic susceptibility to diabetic nephropathy