论文部分内容阅读
目的探讨β连环蛋白(β-catenin)和APC蛋白在卵巢浆液性囊腺癌的表达及临床意义。方法应用免疫组化EnVision法检测24例正常卵巢组织(A组)、44例卵巢浆液性囊腺瘤(B组)、46例卵巢交界性浆液性囊腺瘤(C组)和50例卵巢浆液性囊腺癌(D组)中β-catenin和APC蛋白的表达,分析其与病理分期、分级的关系。结果 D组β-catenin表达低于A组和B组(34.0%vs.83.3%和68.2%)(P<0.05)。D组G1、G2和G3级患者的β-catenin表达率分别为73.3%、50.0%和7.4%(P<0.05);D组国际妇产科联盟(FIGO)Ⅲ、Ⅳ期患者的β-catenin表达率低于Ⅰ、Ⅱ期(12.5%vs.72.2%)(P<0.01)。D组APC蛋白的表达率低于A组和B组(36.0%vs.83.3%和59.1%)(P<0.05)。D组G1、G2和G3级患者的APC蛋白表达率分别为80.0%、50.0%和7.4%(P<0.05);D组FIGOⅠ、Ⅱ期患者的APC蛋白表达低于Ⅲ、Ⅳ期(15.6%vs.72.2%)(P<0.01)。结论β-catenin及APC蛋白在卵巢组织中的表达对卵巢浆液性囊腺癌的发生、发展可能起着重要作用,两者联合检测对卵巢浆液性囊腺癌患者预后的预测有一定临床意义。
Objective To investigate the expression of β-catenin and APC protein in ovarian serous cystadenocarcinoma and its clinical significance. Methods Immunohistochemical EnVision method was used to detect 24 cases of normal ovarian tissue (group A), 44 cases of ovarian serous cystadenoma (group B), 46 cases of ovarian borderline serous cystadenoma (group C) and 50 cases of ovarian serous The expression of β-catenin and APC in the cystadenocarcinoma (group D) was analyzed. The relationship between the expression of β-catenin and APC was analyzed. Results The expression of β-catenin in group D was lower than that in group A and group B (34.0% vs 83.3% and 68.2%, P <0.05). The expression rates of β-catenin in group G1, G2 and G3 were 73.3%, 50.0% and 7.4%, respectively (P <0.05); in group D, the level of β-catenin The expression rate was lower than Ⅰ, Ⅱ (12.5% vs 72.2%) (P <0.01). The expression of APC in group D was lower than that in group A and group B (36.0% vs 83.3% and 59.1%, P <0.05). The APC protein expression of group G1, G2 and G3 were 80.0%, 50.0% and 7.4% respectively in group D (P <0.05) vs 72.2%) (P <0.01). Conclusions The expression of β-catenin and APC protein in ovarian tissue may play an important role in the occurrence and development of ovarian serous cystadenocarcinoma. The combined detection of β-catenin and APC protein has a certain clinical significance in predicting the prognosis of ovarian serous cystadenocarcinoma.