论文部分内容阅读
蛋白尿>4 mg/m~2/hr是严重肾脏病的重要征象。肾病蛋白尿时,清晨尿蛋白/肌酐比率可超过1.8mg蛋白/mg肌酐或尿蛋白排出量超过40mg/m~2/hr时,即有浮肿及其并发症。肾小球疾病患者,除微小病变型肾病综合征外,用皮质激素或细胞毒制剂加强治疗常不能使蛋白尿减轻。为此,作者采用了血管紧张素转化酶(ACE)抑制剂-巯甲丙脯酸治疗8例难治性蛋白尿儿童。开始剂量是12.5～25mg/次(每次0.33～1 mg/kg),每日3次。根据血压改变和尿蛋白排出情况增加剂量,最大剂量为50mg(每次1～2 mg/kg),每日3次。结果 8例患者(女性5例)平均年龄14.9岁(范围5～22岁)。其中狼疮肾炎4例、局灶性节段
Proteinuria> 4 mg / m 2 / hr is a significant sign of severe kidney disease. Kidney disease proteinuria, early morning urine protein / creatinine ratio of more than 1.8mg protein / mg creatinine or urinary protein excretion of more than 40mg / m ~ 2 / hr, that is, edema and its complications. Patients with glomerular diseases, except for minimal-neoplastic nephrotic syndrome, are often unable to relieve proteinuria with intensive treatment with corticosteroids or cytotoxic agents. To this end, the authors used angiotensin-converting enzyme (ACE) inhibitor-captopril in 8 children with refractory proteinuria. The initial dose is 12.5 ~ 25mg / time (0.33 ~ 1 mg / kg each time), 3 times a day. According to blood pressure changes and urinary protein excretion to increase the dose, the maximum dose of 50mg (each 1 ~ 2 mg / kg) 3 times a day. Results Eight patients (5 women) had an average age of 14.9 years (range 5-22 years). Four cases of lupus nephritis, focal segmental