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目的:评价噻托溴铵干粉剂对中、重度稳定期慢性阻塞性肺疾病(COPD)患者肺功能的影响。方法:采用随机对照研究140例COPD患者,噻托溴铵组使用噻托溴铵干粉剂,对照组使用氨茶碱片,总观察时间12周,治疗前后测定肺功能。结果:治疗后噻托溴铵组深吸气量、第1秒用力肺活量和用力肺活量明显改善,分别增加了102mL,256mL和154mL,对照组改善不明显,仅分别增加了10mL,08mL,15mL。结论:噻托溴铵能改善中、重度稳定期COPD患者的肺功能,可提高患者的生活质量。
Objective: To evaluate the effect of tiotropium on lung function in patients with moderate and severe chronic obstructive pulmonary disease (COPD). Methods: A randomized controlled study of 140 patients with COPD, tiotropium group with tiotropium powder, aminophylline tablets in the control group, the total observation time of 12 weeks, before and after treatment of lung function. Results: The values of deep inspiratory volume, forced expiratory volume in 1 second and forced vital capacity in tiotropium group increased by 102 mL, 256 mL and 154 mL respectively after treatment, while no significant improvement was found in the control group, only 10 mL, 08 mL and 15 mL respectively. Conclusion: Tiotropium can improve pulmonary function in patients with moderate and severe stable COPD and improve the quality of life of patients.