论文部分内容阅读
氨苯砜耐药的流行率上升1941年始用砜类药治疗麻风,1953年 Woloot 即报道氨苯砜耐药的可疑病例,1964年才获得临床和实验的证据。目前氨苯砜耐药的流行率已上升到令人吃惊的程度。早在1950年马来西亚 Sungei Buloh 麻风病院采用 DDS 足量监服治疗,1964年 Rees 和 Pettit 确诊第一例氨苯砜耐药,当时其耐药发生率约1‰,以后的10年却增加了25倍,现在约100‰。氨苯砜耐药已是世界性的问题,至少从25个国家已分离出氨苯砜耐药菌株,有些国家多菌型麻风氨苯砜耐药发生率竟达50‰。
The prevalence of dapsone increased in 1941 with sulfone drugs for the treatment of leprosy. Woloot in 1953 reported suspicious cases of dapsone resistance, obtaining clinical and experimental evidence in 1964. The current prevalence of dapsone resistance has risen to alarming levels. As early as 1950, Sungei Buloh leprosy hospital in Malaysia using DDS adequate supervision and treatment, 1964 Rees and Pettit confirmed the first case of dapsone resistance, when its resistance rate of about 1 ‰, the next 10 years has increased by 25 Times, now about 100 ‰. Dapsone resistance is a worldwide problem. Dapsone has been isolated from at least 25 countries. In some countries, the incidence of multidrug-resistant leprosy was as high as 50 per 1,000.