论文部分内容阅读
目的 探讨合并肝硬化的外科患者围手术期治疗中抗生素的合理应用和手术感染因素防治措施。方法 随机设立治疗组和对照组 ;治疗组应用预定的原则在围手术期全程预防性使用抗生素 ,发生感染时抗生素可升级使用或根据药敏结果使用 ;对照组则只在术后发生感染时对症使用抗生素 ;由此比较两组病例的术后感染率和手术死亡率。结果 治疗组的术后感染率 13.6 % ,显著低于对照组 2 9.2 % ,P<0 .0 5 ,治疗组与对照组的术后合并症发生率和死亡率也有明显不同。结论 合并肝硬化的外科患者在围手术期预防性使用抗生素治疗 ,可以有效降低术后感染发生率和手术死亡率 ;肝硬化患者术后感染的主要部位是腹腔 ,主要原因是免疫功能减低和肠道内G- 杆菌的腹腔移位 ;术前加强保肝治疗是预防术后感染的基本步骤
Objective To investigate the rational use of antibiotics in the surgical treatment of patients with cirrhosis and the prevention and treatment of surgical infection factors. Methods The treatment group and the control group were randomly established. The treatment group used the predetermined principle to prevent the use of antibiotics throughout the perioperative period, and the antibiotics could be upgraded or used according to the susceptibility results when the infection occurred. The control group only showed symptoms after the operation The use of antibiotics; thus comparing the two groups of cases of postoperative infection and operative mortality. Results The postoperative infection rate in the treatment group was 13.6%, which was significantly lower than that in the control group (9.22%, P <0.05). There was also a significant difference in postoperative morbidity and mortality between the treatment group and the control group. CONCLUSIONS: Perioperative prophylactic use of antibiotics in surgical patients with cirrhosis can effectively reduce the incidence of postoperative infection and operative mortality. The main site of postoperative infection in patients with cirrhosis is the abdominal cavity, mainly due to decreased immune function and intestinal Intra-tract G-Bacillus peritoneal shift; Preoperative liver protection is to strengthen the prevention of postoperative infection of the basic steps