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乙醛脱氢酶2是体内重要的醛类代谢酶。我们的前期研究发现,乙醛脱氢酶2可有效抑制酒精摄入引起的心肌损伤,并提示可能存在更为广泛的心肌保护作用。本研究中,我们采用乙醛脱氢酶2过表达和基因敲除(ALDH2 KO)小鼠探讨乙醛脱氢酶2对缺血再灌注(I/R)心脏的保护作用及其细胞机制。我们证实乙醛脱氢
Acetaldehyde dehydrogenase 2 is an important aldehyde metabolizing enzyme in the body. Our previous study found that ALDH 2 can effectively inhibit myocardial damage caused by alcohol intake, and suggests that there may be more extensive myocardial protection. In this study, we used ALDH2 overexpression and knockout (ALDH2 KO) mice to investigate the protective effect of ALDH2 on ischemia / reperfusion (I / R) heart and its cellular mechanism. We confirmed acetaldehyde dehydrogenation