日前,上海交通大学赵立平团队与中科院上海生命科学研究院营养科学研究所刘勇团队、国家人类基因组南方中心赵国屏团队合作,发现热量限制能促进肠道益菌的生长,从而令小鼠增加寿命。该研究表明,节食或许通过造成一个更健康的菌群来促进宿主健康,相关研究论文发表在《自然-通讯》上。通过减少食物摄入量,从而限制热量摄入在很多动物模型中被证明能够有效延缓衰老和延长寿命。虽然很难在人群中开展全生命周期的节食实验,但以人为对象的短期实验同样证明,不造成营养不良的节食干预对健康有益。关于节食的作用机理,科学家已经进行了大量研究,提出了各种假说、找出了一些相关的基因及调控通路,但是仍然还有许多未知环节需要继续深入研究。 Recently, ZHAO Li-ping team from Shanghai Jiao Tong University cooperated with Liu Yong team of Institute of Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and team of Zhao Guobin from South China National Human Genome Center. They found that caloric restriction can promote the growth of intestinal probiotics, thus increasing the lifespan of mice. The study shows that dieting may promote host health by creating a healthier flora that is published in Nature - Communications. Limiting caloric intake by reducing food intake has been shown to delay aging and prolong life in many animal models. Although it is difficult to carry out full-life dieting trials in the population, short-term human-based trials have also shown that dieting interventions that do not cause malnutrition are good for health. On the mechanism of diet, scientists have conducted a large number of studies, put forward various hypotheses, and found some related genes and regulatory pathways, but there are still many unknown aspects need further study.