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目的:了解本地区妊娠合并丙型肝炎病毒(hepatitis C virus,HCV)感染孕妇占妊娠合并感染性疾病的构成比变化,妊娠合并HCV感染母婴传播情况,为疾病控制提供临床依据。方法:对2008年至2012年东南大学附属第二医院妇产科收治的162例妊娠合并HCV感染孕妇的临床资料进行回顾性分析,分析妊娠合并HCV感染孕妇的构成比变化,观察孕期丙型肝炎活动情况,随访HCV感染孕妇的婴儿,分析HCV的母婴传播情况。结果:妊娠合并HCV感染孕妇的构成比是3.34%(162/4 848),近5年妊娠合并HCV感染孕妇的构成比无明显变化;孕期发现有37例孕妇ALT异常,孕期肝炎活动率22.84%(37/162);144例新生儿HCV抗体均为阳性,4例新生儿HCV RNA阳性;随访到18个月有4例婴儿HCV抗体阳性,考虑发生HCV感染。结论:近5年HCV感染孕妇在妊娠合并感染性疾病中的比例无明显变化;孕妇HCV可以传染给婴儿;HCV抗体可以通过胎盘进入胎儿体内。
OBJECTIVE: To understand the changes of pregnancy-associated infectious diseases among pregnant women with hepatitis C virus (HCV) infection in pregnancy and pregnancy, and to provide a clinical basis for disease control. Methods: The clinical data of 162 pregnant women with pregnancy-associated HCV infection admitted to the Obstetrics and Gynecology Center of the Second Affiliated Hospital of Southeast University from 2008 to 2012 were retrospectively analyzed. The changes in the constituent ratios of pregnant women with HCV infection during pregnancy were analyzed. Activity, follow-up of infants infected with HCV-infected pregnant women, analysis of mother-to-child transmission of HCV. Results: The constituent ratio of pregnant women with HCV infection in pregnancy was 3.34% (162/4848). There was no significant difference in the constituent ratio of pregnant women with HCV infection during the past 5 years. In pregnancy, 37 cases of pregnant women were found to have abnormal ALT, hepatitis activity rate during pregnancy was 22.84% (37/162). All 144 neonates had positive HCV antibodies and 4 were positive for HCV RNA. Four of the infants were positive for HCV antibody at 18 months of follow-up, and HCV infection was considered. CONCLUSIONS: The proportion of HCV-infected pregnant women in pregnancy-related infectious diseases has not changed significantly in the recent 5 years. HCV in pregnant women can be transmitted to infants. HCV antibodies can enter the fetus through the placenta.