The aim of this study was to evaluate the relationship between the embryo resorption rate (RR) and the status of local immunity at the feto-maternal interface in pregnant NOD/SCID mice. RR was calculated in NOD/SCID×NOD/SCID mice and compared with non-immunodeficiency BALB/c×BALB/c mice on day 13.5 of gestation. Intracellular detection of cytokine expression was performed with four-color flow cytometry to identify the functional subsets of lymphocytes in NOD/SCID mice before being bred or during pregnancy. No statistically supported difference in RRs was observed between NOD/SCID×NOD/SCID and control BALB/c×BALB/c mice. Accordingly, although multiple immunodeficits were confirmed in NOD/SCID mice, the percentages of several functional cell subsets were spontaneously altered during pregnancy, and this may be correlated with the roughly normal pregnancy outcomes observed in these mice. The spontaneous alteration of cell percentages at the feto-maternal interface in NOD/SCID mice may be of benefit to the pregnancy outcomes. The aim of this study was to evaluate the relationship between the embryo resorption rate (RR) and the status of local immunity at the feto-maternal interface in pregnant NOD / SCID mice. RR was calculated in NOD / SCID × NOD / SCID mice and compared with non-immunodeficiency BALB / c × BALB / c mice on day 13.5 of gestation. Intracellular detection of cytokine expression was performed with four-color flow cytometry to identify the functional subsets of lymphocytes in NOD / SCID mice before being bred or during pregnancy . No, statistically significant difference in RRs was observed between NOD / SCID × NOD / SCID and control BALB / c × BALB / c mice. altered during pregnancy, and this may be correlated with the roughly normal pregnancy outcomes observed in these mice. The spontaneous alteration of cell percentages at the feto-maternal interface in NOD / SCID mice may be of benefit to the pregnancy outcomes.