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目的探讨高压氧(HBO)治疗后立即放射治疗宫颈癌的疗效和应用价值。方法随机选择确诊为Ⅱ～Ⅲ期宫颈癌的患者58例,其中28例设为HBO组,30例为对照组。2组均常规采用60Co外照射+腔内后装治疗,HBO组在每次放射治疗前行HBO治疗,出舱后25 min内行放射治疗。结果HBO组完全缓解率(CR)为75．0％,总有效率(CR+PR)为92．8％,3年生存率为71．4％,局部复发率为10．7％,与对照组比较,差异有统计学意义(P<0．05);而且HBO组放射治疗副反应及并发症亦明显减少。结论HBO治疗后立即放射治疗是提高宫颈癌放射治疗疗效的有效途径。选择合理的对象和应用时机是提高疗效的关键环节。
Objective To investigate the curative effect and application value of radiotherapy for cervical cancer after hyperbaric oxygen (HBO) treatment. Methods Fifty-eight patients with cervical cancer diagnosed as stage Ⅱ ~ Ⅲ were randomly selected, of which 28 were HBO group and 30 were control group. Both groups were routinely treated with 60Co external irradiation + intracavitary after-treatment, and HBO group received HBO before each radiotherapy. Radiotherapy was performed within 25 min after exiting the capsule. Results The complete remission rate (CR) of HBO group was 75.0%, the total effective rate (CR + PR) was 92.8%, the 3-year survival rate was 71.4% and the local recurrence rate was 10.7% Group, the difference was statistically significant (P <0.05); and HBO group radiation side effects and complications also significantly reduced. Conclusion Radiation therapy immediately after HBO treatment is an effective way to improve the efficacy of radiation therapy for cervical cancer. Choose a reasonable target and timing is to improve the effectiveness of the key link.