多囊卵巢综合征时,由于不能完全分开卵巢和肾上腺的机能,对于产生过量雄激素的特殊腺体来源尚有争议。对于人类,由于没有一种制剂能选择性地抑制卵巢或肾上腺,因而在选择性刺激之前,无法分开这些组织。新近,有报道给患内膜异位症的正常排卵妇女注射长效促性腺激素释放激素的高活性类似物(GnRH-A)可使血清雌二醇及雌酮水平降低至阉割妇女的水平,因而可用此方法达到药物性可逆卵巢切除。这种情况下也观察到循环雄甾烯二酮和睾酮水平下降。为确定注射GnRH-A是否能用于选择性地抑制卵巢甾体激素的分泌,本工作在多囊卵巢综合征妇女及正常排卵妇女,测定了注射GnRH-A之前和用药之末血清促性腺激 Polycystic ovary syndrome, because can not completely separate the function of the ovary and the adrenal gland, for generating excessive androgen special gland source is still controversial. In humans, none of these tissues can be separated before selective stimulation, as no agent selectively inhibits the ovary or adrenal gland. Recently, it has been reported that injecting a highly active analog of long-acting gonadotropin-releasing hormone (GnRH-A) to normal ovulation women with endometriosis has been shown to reduce serum estradiol and estrone levels to those of castrated women, This method can be used to achieve the drug reversible ovariectomy. Cyclic androstenedione and testosterone levels were also observed to decrease in this case. To determine whether GnRH-A can be used to selectively inhibit ovarian steroid hormone secretion, this work in women with polycystic ovary syndrome and normal ovulation women, measured before and after injection of GnRH-A serum gonadal stimulation