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目的探讨89SrCl2治疗转移性骨肿瘤的临床应用价值和特点。方法504例有不同程度骨痛、伴或不伴活动受限的广泛转移性骨肿瘤患者,静脉注射89SrCl21.48～2.22MBq/kg体重。随访时间最短3个月,最长4.5年。结果89SrCl2治疗后无效(疼痛无明显变化,活动能力无改善)97例,占19.2%;有效(疼痛明显减轻,活动能力有改善)298例,占59.1%;显效(疼痛基本消失,活动能力明显恢复)109例,占21.6%。总有效率为80.8%。疗效发生在89SrCl2治疗后1～46d(大多在14d内),疗效维持56d至13个月以上(大多数为4～10个月)。部分患者复查骨显像显示,原异常浓聚影明显缩小、减少和(或)消失。80.0%患者在接受89SrCl2治疗后的4～6周白细胞和血小板计数有轻、中度下降,55.0%曾下降至正常水平以下。经对症处理后,大多数患者在3～6个月内,1/3患者在7～9个月内,个别患者在1年左右恢复到治疗前水平。血象的变化与疗效无明显相关性。结论89SrCl2可以安全、有效地缓解骨转移癌所致疼痛,大多数患者的生活质量有所改善,部分患者病灶缩小或消失。
Objective To investigate the clinical value and characteristics of 89SrCl2 in the treatment of metastatic bone tumors. Methods A total of 504 patients with extensively metastatic bone tumors with varying degrees of bone pain, with or without limited mobility, were given intravenous 89SrCl 21.48-2.22 MBq / kg of body weight. The shortest follow-up time of 3 months, the longest 4.5 years. Results After 89SrCl2 treatment, 97 patients (19.2%) were ineffective (no obvious change in pain, no improvement in activity), 298 patients (59.1%) were effective (pain was relieved and mobility was improved), markedly effective Recovery) 109 cases, accounting for 21.6%. The total effective rate is 80.8%. Efficacy occurred in 89SrCl2 treatment 1 ~ 46d (mostly in 14d), the efficacy of maintenance of 56d to 13 months or more (mostly 4 to 10 months). Some patients review the bone imaging showed that the original abnormal concentration shadow was significantly reduced, reduced and (or) disappear. Eighty percent of patients had mild to moderate leukocyte and platelet counts 4 to 6 weeks after treatment with 89SrCl2, and 55.0% had dropped below normal levels. After symptomatic treatment, most patients within 3 to 6 months, 1/3 of patients within 7 to 9 months, individual patients return to pre-treatment level in about 1 year. Blood changes and no significant correlation between efficacy. Conclusion 89SrCl2 can relieve the pain caused by bone metastases safely and effectively. The quality of life of most patients is improved, and the lesions of some patients shrink or disappear.