论文部分内容阅读
脑肿瘤的缺少修复酶活性(Mer-)肿瘤细胞对属于氯甲基亚硝酸脲(CENU)类的嘧啶亚硝脲(ACNU)敏感,而Mer-细胞有耐药性。同样在移植脑肿瘤模型通过ACNU亦可大量治愈Mer-肿瘤,但Mer-肿瘤对治疗有耐药性,实验证实了~6O-甲基鸟嘌呤-甲基转换酶(MGMT)活性与ACNU密切相关。人脑肿瘤组织的MGMT活性在化疗适应症的恶性神经胶质瘤中约30％为60fmol/mg以下者,估计存在Mer-肿瘤。在非神经
Brain tumor lacking repair enzyme activity (Mer-) Tumor cells are sensitive to pyrimidine nitrosourea (ACNU) belonging to the class of chloromethyl nitrite (CENU), whereas Mer-cells are resistant. Also in the transplanted brain tumor model by ACNU can also be a large number of Mer-tumor, but Mer-tumor resistance to treatment, experiment confirmed that ~ 6O-methylguanine-methyltransferase (MGMT) activity and ACNU are closely related . MGMT activity in human brain tumor tissues Approximately 30% of chemotherapy-induced malignant gliomas are below 60 fmol / mg, and Mer-tumors are estimated to be present. In the non-nerve