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中药及其制剂引起的药物不良反应,多因超量或用法不当造成中毒甚至死亡,笔者统计的1152例中,345例是由于上述原因引起的,占29.9％,其中植物类中药引起占90％以上,主要有乌头碱类药物(川、草乌及附子)。该类药物的有毒成份为乌头碱,有剧毒,其晶体0.2mg即可中毒,其致死量为2～4mg。另一个为雷公藤及其制剂,朱天忠搜集的1981年以来涉及雷公藤中毒死亡的资料对该药的毒理等进行了初步探讨。
The drug adverse reactions caused by traditional Chinese medicine and its preparations are often caused by excessive or improper use of poisoning or even death. Among the 1,152 cases reported by the author, 345 were caused by the above reasons, accounting for 29.9%, of which 90% were caused by plant herbal medicines. Above, there are mainly aconitine drugs (Chuan, Kusao and Fuzi). The toxic ingredient of this type of drug is aconitine, which is highly toxic and its crystal 0.2mg can be poisoned, the lethal dose is 2 ~ 4mg. The other was Tripterygium wilfordii and its preparations. Zhu Tianzhong’s collection of information on the death caused by tripterygium wilfordii from 1981 on the toxicological properties of the drug was preliminary discussed.