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采用简单小室法，以离体小白鼠皮肤为透皮屏障，用生理盐水为接受液，研究了不同浓度的氮酮对甘草次酸钠透皮吸收的影响。实验结果表明：含２．０％、１．０％、０．５％氮酮的甘草次酸钠贴剂与不含氮酮的甘草次酸钠贴剂间，其透皮吸收有极显著差异（Ｐ＜０．０１），而含２．５％氮酮的甘草次酸钠贴剂与不含氮酮的甘草次酸钠贴剂间，其透皮吸收无显著性差异（Ｐ＞０．０５）；含不同浓度氮酮的甘草次酸钠贴剂间，其透皮吸收无显著性差异（Ｐ＞０．０５）；但以含２．０％氮酮的甘草次酸钠贴剂，其透皮吸收为最好。
A simple chamber method was used to study the effects of different concentrations of Azone on the transdermal absorption of glycyrrhizin sodium through transdermal skin of isolated mouse and saline as the receiving solution. The experimental results showed that there was a significant difference in transdermal absorption between sodium glycyrrhetinate patch containing 2.0%, 1.0%, 0.5% azone and sodium glycyrrhetinate patch without azone, (P <0.01). However, there was no significant difference in the transdermal absorption between the glycyrrhizin patch containing 2.5% Azone and the patch containing sodium glycyrrhizinate without Azone (P> 0.05). 05). There was no significant difference in percutaneous absorption of sodium glycyrrhetinate with different concentrations of Azone (P> 0.05) Its transdermal absorption is the best.