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应用傅里叶变换红外光谱 (FTIR)法对 184例不同病理状态的胃镜下活检组织样品进行检测和分析 ,结果表明 ,慢性浅表性胃炎的基本谱图特征包括 :较强的酰胺Ⅱ带 ;14 6 0cm-1处的峰强高于 14 0 0cm-1处的峰强。典型的胃癌组织的谱图特征包括 :较低的酰胺Ⅱ带 ;14 6 0cm-1处的峰强低于 14 0 0cm-1处的峰强 ;130 0cm-1的峰强明显增加。慢性萎缩性胃炎呈现出部分胃癌的光谱特征。这一结果表明 ,应用FTIR可以对胃镜下活检的小块组织进行鉴别诊断。
The results of gastroscopic biopsy of 184 cases with different pathological states were analyzed by Fourier transform infrared spectroscopy (FTIR). The results showed that the basic spectral characteristics of chronic superficial gastritis were: strong amide Ⅱ band; The peak intensity at 1460 cm-1 is higher than the peak intensity at 1400 cm-1. The spectral characteristics of a typical gastric cancer tissue include: the lower amide II band; the peak intensity at 1460 cm-1 is lower than the peak intensity at 140 cm-1; and the peak intensity at 130 0 cm-1 is significantly increased. Chronic atrophic gastritis shows the spectral features of some gastric cancers. This result shows that the application of FTIR can differentiate small sections of endoscopic biopsies.