19世纪初,根据甲状腺激素不能使脑组织耗氧量增加的实验结果,认为脑属于对甲状腺激素不敏感的器官,甚至认为脑对甲状腺激素根本不发生反应。后来,大量临床和实验室观察都证明,甲状腺功能低下或亢进可使脑组织的形态、生化和机能发生一系列损害,因此,怀疑脑对甲状腺激素不发生反应的论点。近年来,对甲状腺激素作用的分子机制和甲 Early 19th century, according to thyroid hormone can not make the brain tissue oxygen consumption increased experimental results, that the brain belongs to the thyroid hormone-insensitive organ even think that the brain does not react to thyroid hormone. Later, a large number of clinical and laboratory observations have proved that hypothyroidism or hyperthyroidism can make a a series of damage to the morphology, biochemistry and function of brain tissue, therefore, suspected brain thyroid hormone does not react to the argument. In recent years, the molecular mechanism of thyroid hormone action and a