Calcium(Ca2+)and magnesium(Mg2+)influence the molecular pathways of ischemic neuronal death.The authors evaluated the impact of admission serum Ca2+and Mg2+levels,on incident stroke severity and discharge functional outcome.After adjusting for covariates,higher admission Ca2+was significantly associated with lesser stroke severity and better discharge functional outcome.Admission Mg2+was not an independent clinical outcome prognosticator. Calcium (Ca2 +) and magnesium (Mg2 +) influence the molecular pathways of ischemic neuronal death. These authors evaluated the impact as admission of serum serum Ca2 + and Mg2 + levels, on incident stroke severity and discharge functional outcome. After adjusting for covariates, higher admission Ca2 + was significantly associated with lesser stroke severity and better discharge functional outcome. Admission Mg2 + was not an independent clinical outcome prognosticator.