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我们于1966年用狗的草酸钠抗凝血浆,以部分凝血活酶时间、凝血酶元时间(PT)及凝血酶时间(TT)对83味中草药作了初筛试验,发现有些中草药使狗的血液凝固时间延长。为了寻找防治弥漫性血管内凝血安全而有效的抗凝药物,我们对初筛中查出有“抗凝”作用的药物以兔血浆复筛,再次肯定艾叶、丹参、鸡血藤、活血藤等药物亦能使兔血浆高岭土部分凝血活酶时间(KPTT)、PT 及 TT 明显延长或不凝。为此,我们用正常人草酸钠抗凝血浆对艾叶和丹参作了进一步研究,并用生理盐水、肝素化及链激酶化血浆作对比观察。关于丹参的抗
We used dog’s sodium oxalate anticoagulant plasma in 1966, and conducted a preliminary screening test of 83 Chinese herbal medicines with partial thromboplastin time, thrombin time (PT), and thrombin time (TT), and found that some Chinese herbs make dog’s Blood clotting time is extended. In order to find safe and effective anticoagulant drugs for prevention and treatment of disseminated intravascular coagulation, we re-screened rabbit plasma with anticoagulant drugs identified in the initial screening, and reaffirmed that leaves, Salvia miltiorrhiza, Millettia spp., Huoxue et al. The drug can also significantly prolong or not coagulate plasma kaolin partial thromboplastin time (KPTT), PT, and TT in rabbits. To this end, we used normal human oxalate anticoagulant plasma to further study the leaves and Danshen, and compared with normal saline, heparinized and streptokinated plasma. About the resistance of Danshen