目的:观察头孢类药物联合阿奇霉素在治疗小儿急性呼吸道感染的临床疗效和安全性。方法:选取168例诊断为急性呼吸道感染的患儿,随机分为Ⅰ、Ⅱ、Ⅲ三组,Ⅰ组给予头孢噻肟钠,Ⅱ组给予阿奇霉素,Ⅲ组给予头孢噻肟钠+阿奇霉素,观察对比三组患者总体有效率、临床症状消失时间及不良反应发生率。结果:Ⅲ组患者临床疗效高于Ⅰ、Ⅱ组(P<0.05),Ⅲ组患者临床症状消失时间快于Ⅰ、Ⅱ组(P<0.05)差异具有统计学意义,Ⅲ组患者不良反应发生率与Ⅱ组比较差异无统计学意义(P>0.05)。结论:头孢类药物联合阿奇霉素治疗小儿急性呼吸道感染疗效显著,症状缓解快,安全可靠。 Objective: To observe the clinical efficacy and safety of cephalosporins combined with azithromycin in the treatment of pediatric acute respiratory infection. Methods: A total of 168 children diagnosed as acute respiratory infection were selected and randomly divided into three groups: Ⅰ, Ⅱ and Ⅲ. Group Ⅰ received cefotaxime sodium, group Ⅱ received azithromycin and group Ⅲ received cefotaxime sodium and azithromycin. The overall efficiency of three groups of patients, the disappearance of clinical symptoms and the incidence of adverse reactions. Results: The clinical curative effect of group Ⅲ was higher than that of group Ⅰ and Ⅱ (P <0.05), and the disappearance time of clinical symptoms in group Ⅲ was faster than that of group Ⅰ and Ⅱ (P <0.05). The incidence of adverse reactions in group Ⅲ There was no significant difference between the two groups (P> 0.05). Conclusion: The cephalosporins combined with azithromycin has a significant therapeutic effect on acute respiratory infection in children, and its symptoms are relieved quickly and safely.