论文部分内容阅读
腹腔注射二甲基亚硝胺(DMN)诱发大鼠肝纤维化,分别用国产RNA(4mg/kg)和C_0Q_(10)(2.5mg/kg)治疗,另设正常对照和病理对照组。治疗后30、60和90天活杀,作血清酶学、氨基酸检测,胶原纤维定量及电镜检查,结果表明RNA和C_0Q_(10)治疗组AST,γ-GT均在正常范围,A/G比值与病理对照组同期比较明显降低(P<0.01),RNA组ALT,MAO和ANG明显下降(P<0.01),血清氨基酸水平升幅较小(P<0.01),光镜检查也显示RNA治疗组肝细胞变性坏死程度,以及胶原纤维定量代表的肝纤维化程度都比较轻,有显著意义。电镜检查从超微结构水平也证实了上述结果。RNA有降酶保肝和抗肝纤维化的作用。
Intraperitoneal injection of dimethylnitrosamine (DMN) induced hepatic fibrosis in rats, which were treated with domestic RNA (4mg/kg) and C_0Q_(10) (2.5mg/kg), and normal control and pathological control group were set up. After 30, 60, and 90 days of treatment, they were sacrificed for serum enzymology, amino acid detection, collagen fiber quantification, and electron microscopy. The results showed that both AST and γ-GT in the RNA and C_0Q_(10) treatment groups were in the normal range, and the A/G ratio was Compared with the pathological control group, the levels of ALT, MAO and ANG in the RNA group decreased significantly (P<0.01), and the serum amino acid levels increased less (P<0.01). The extent of cell degeneration and necrosis, as well as the extent of hepatic fibrosis quantified by collagen fibers, were all mild and significant. Electron microscopy also confirmed the above results from the ultrastructural level. RNA has a protective effect against liver and liver fibrosis.