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代谢综合征(Metabolic Syndrome,MS)又称胰岛素抵抗综合征,是多种代谢紊乱在同一患者体内聚集的现象。目前,肥胖与糖尿病已经成为人类健康十大威胁之一,对其防治措施的研究已刻不容缓。2 型糖尿病占糖尿病总数90％,其中80％伴有肥胖或超重,是代谢综合征的中晚期表现。2型糖尿病和脂毒性密切相关,因此,又有“糖胖病”和“糖脂病”之称,而噻唑烷二酮类药物具有减少胰岛素原的分泌, 阻止胰岛β细胞的凋亡,故能长期稳定控制血糖。 1 代谢综合征的临床意义 MS是很常见的临床综合征,按WHO1998年提出的工作定义,如患者有2型糖尿病,糖耐量低减或胰岛素抵抗,同时具备以下条件4种情况中的2 种即可称之为代谢综合征:①血压≥140／90mmHg,
Metabolic Syndrome (MS), also known as Insulin Resistance Syndrome, is a phenomenon in which many metabolic disorders accumulate in the same patient. At present, obesity and diabetes have become one of the top ten threats to human health, and research on their prevention and control measures has been urgently needed. Type 2 diabetes accounts for 90% of the total number of diabetic patients, of which 80% are obese or overweight and are intermediate and advanced manifestations of metabolic syndrome. Type 2 diabetes and lipid toxicity are closely related, therefore, there are “obesity” and “glycolipopathies,” said, and thiazolidinedione drugs have reduced the secretion of proinsulin, pancreatic islet β cells to prevent apoptosis, so Long-term stable control of blood sugar. 1 Clinical significance of metabolic syndrome MS is a very common clinical syndrome, according to the WHO 1998 trial of patients prescribed defensive, such as patients with type 2 diabetes, impaired glucose tolerance or insulin resistance, with the following conditions in 4 cases of 2 Can be called metabolic syndrome: ① blood pressure ≥ 140 / 90mmHg,