Background: Enhanced recovery after surgery (ERAS) has shown effectiveness in terms of reducing the hospital stay and cost. However, the benefit of ERAS in patients undergoing hepatectomy for benign liver lesions is still unclear.Methods: ERAS was implemented in our center since March 1st, 2018. From September 2016 to Febru- ary 2018, 109 patients were enrolled into the control group, and from March 2018 to June 2019, 124 patients were enrolled into the ERAS group. All the indicators related to operation, liver functions, and postoperative outcomes were included in the analysis. Results: The clinicopathologic baselines were similar in these two groups. A significantly higher propor- tion of patients underwent laparoscopic surgery in the ERAS group. On the whole, intraoperative blood loss (100.00 mL vs . 200.00 mL, P < 0.001), blood transfusion (3.23％ vs. 10.09％, P = 0.033), total bilirubin (17.10 μmol/L vs . 21.00 μmol/L, P = 0.041), D -dimer (2.08 μg/mL vs. 2.57 μg/mL, P = 0.031), postoperative hospital stay (5.00 d vs. 6.00 d, P < 0.001), and postoperative morbidity (16.13％ vs. 32.11％, P = 0.008) were significantly shorter or less in the ERAS group than those in the control group. After stratified by operation methods, ERAS group showed significantly shorter postoperative hospital stay in both open and laparoscopic operation (both P < 0.001). In patients underwent open surgery, ERAS group demonstrated significantly shorter operative duration (131.76 ± 8.75 min vs. 160.73 ± 7.23 min, P = 0.016), less intra- operative blood loss (200.00 mL vs. 450.00 mL, P = 0.008) and less postoperative morbidity (16.00％ vs. 44.44％, P = 0.040). Conclusions: ERAS program may be safe and effective for the patients underwent hepatectomy, especially open surgery, for benign liver lesions.