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Objective To investigate the interaction and c linical significance of changes in p lasma endothelin-1(ET-1)and prostacyclin(PGI 2 )concentrations in patients with isc hemic cerebral infarction.Methods Plasma ET-1and 6-keto-PGF 1 α(resistant metabolite of PGI 2 )concentrations were measured in 37p atients(study group)with ischemic cerebral infarction a nd 34healthy volunteers(control group)by ra-dioimmunoassay.Results Plasma ET-1concentrations in patie nts of study group were markedly higher than that of control group(P <0.01)and 6-keto-PGF 1 αconcentrations in patients of study group were significantly lower than that of control subjects(P <0.01).Plasma ET-1concentrations in control subjects were positively correlated with 6-k eto-PGF 1 αconcentrations and no correlation i n the study group.Conclusion Both ET-1and PGI 2 are participated in patho-physiolo gic process of ischemic cerebral inf arction.ET-1is a virulence factor a nd may play a deleterious role in ischemic cerebral infarction,PGI 2 is a conservancy factor and endogenetic antagonist of ET-1.It may provid e useful therapy parameter to find out ectogenesis PGI 2 or analog for treating the patients with ischemic cerebral infarction wi th reason.
Objective To investigate the interaction and c Significance of changes in p lasma endothelin-1 (ET-1) and prostacyclin (PGI 2) concentrations in patients with isc hemic cerebral infarction. Methods Plasma ET-1 and 6-keto-PGF 1 α resistant metabolite of PGI 2) were measured in 37p at patients (study group) with ischemic cerebral infarction a nd 34 healthy volunteers (control group) by ra-dioimmunoassay. Results Plasma ET-1 concentrations in patients of study group were markedly higher than that of control group (P <0.01) and 6-keto-PGF 1 αconcentrations in patients of study group were significantly lower than that of control subjects (P <0.01) .Plasma ET-1concentrations in control subjects were positively correlated with 6-k eto- PGF 1αconcentrations and no correlation in the study group. Conclusions Both ET-1 and PGI 2 were participated in the patho-physiolo gic process of ischemic cerebral infarction. ET-1is a virulence factor a nd may play a de leterious role in ischemic cerebral infarction, PGI 2 is a conservancy factor and endogenetic antagonist of ET-1. It may provid e useful therapy parameter to find out ectogenesis PGI 2 or analog for treating the patients with ischemic cerebral infarction wi th reason.