目的考察辅酶Q10脂质体静脉给药后在小鼠体内的药代动力学和组织分布。方法采用乙醇注入法制备辅酶Q10脂质体,静脉注射给药后,HPLC法测定小鼠血浆和组织中辅酶Q10浓度变化。结果辅酶Q10脂质体的t1/2和AUC均为溶液剂的1.54倍,辅酶Q10脂质体在心、脾、肺中分布增加,尤以心中增加明显。结论辅酶Q10脂质体延缓了药物释放,提高了生物利用度,增强了靶向性作用。 Objective To investigate the pharmacokinetics and tissue distribution of coenzyme Q10 liposomes in mice after intravenous administration. Methods Coenzyme Q10 liposomes were prepared by ethanol injection. After intravenous injection, the concentration of coenzyme Q10 in plasma and tissue of mice was determined by HPLC. Results Both the t1 / 2 and AUC of coenzyme Q10 liposomes were 1.54 times of that of the solution. The distribution of coenzyme Q10 liposomes increased in heart, spleen and lung, especially in the heart. Conclusions Coenzyme Q10 liposomes delay drug release, improve bioavailability and enhance the targeting effect.