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应用流式细胞仪(flowcytometry,FCM)结合单克隆抗体CD16检测了24例白血病患儿治疗前后外周血中NK细胞数量。结果显示:在急性白血病患儿治疗前后NK细胞有明显变化,且均与正常对照组有明显差异。结果提示:NK细胞下降可能是白血病的特征之一,它在白血病发生发展中的意义有待于进一步探讨。
The number of NK cells in peripheral blood of 24 children with leukemia was detected by flow cytometry (FCM) combined with monoclonal antibody CD16. The results showed that in patients with acute leukemia before and after treatment NK cells have significant changes, and both were significantly different from the normal control group. The results suggest that the decline of NK cells may be one of the characteristics of leukemia and its significance in the development of leukemia remains to be further explored.