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为探讨联合化疗在鼻咽癌治疗中的作用，从１９９０年７月至１９９１年１２月把７６例经病理证实、初治的局部晚期（Ⅲ、Ⅳ期）鼻咽癌，随机分为联合化疗和放射治疗组（综合治疗组）以及单纯放疗组（对照组）各３８例。化疗方案：顺铂、氟脲嘧啶和平阳霉素。治疗３月后，综合治疗组和对照组鼻咽肿瘤完全消退率分别为８９．５％和９７．５％，颈转移灶完全消退率分别为９３．８％和９０．６％，两组均无显著性差异（Ｐ＞０．０５）。随访３年，综合治疗组和对照组３年生存率分别为６８．４％和６１．１％（ｘ２＝０．２８２）、无瘤生存率为６３．２％和４８．６％（ｘ２＝０．７３５）．无远处转移生存率为７０．７％和５６．１％（ｘ２＝１．３８２）．鼻咽肿瘤控制率为８４．７％和７７．５％（ｘ２＝０．３９４），颈转移灶控制率为８０．１％和８２．８％（ｘ２＝０．３８３），均无显著差异
To explore the role of combined chemotherapy in the treatment of nasopharyngeal carcinoma, from July 1990 to December 1991, 76 patients with locally advanced (stage III, IV) nasopharyngeal carcinoma confirmed by pathology were randomly divided into combined chemotherapy And radiotherapy group (comprehensive treatment group) and radiotherapy group (control group) each 38 cases. Chemotherapy regimens: cisplatin, fluorouracil and pingyangmycin. After 3 months of treatment, the complete regression rate of the nasopharyngeal tumors in the comprehensive treatment group and the control group were 89.5% and 97.5%, and the complete regression rate of the neck metastasis was 93.8% and 90.6% respectively. No significant difference (P> 0.05). After 3 years of follow-up, the 3-year survival rates of the combination therapy group and the control group were 68.4% and 61.1% (x2 = 0.282), respectively. The tumor-free survival rates were 63.2% and 48.6% 0.735). No distant metastasis survival rates were 70.7% and 56.1% (x2 = 1.382). Nasopharyngeal tumor control rates were 84.7% and 77.5% (x2 = 0.394), neck metastasis control rates were 80.1% and 82.8% (x2 = 0.383), no significant difference