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目的:乳腺癌是妇女常见恶性肿瘤,唐山地震后乳腺癌的发病存在众多特有的发病因素,其发病特点有所变化。方法:2006年7月~2011年7月,来自唐山市工人医院、唐山市妇儿医院、唐山市人民医院、河北联合大学附属医院,新收治的800例乳腺癌患者为研究组。对照组为上述医院收治的非恶性肿瘤、非内分泌系统、非生殖系统疾病的800例患者,并保证两组间的日常暴露一致。所有实验对象均经历过唐山地震,并一直在该地区居住。应用Logistic回归模型分析各个危险因素与乳腺癌病因的关系。结果:研究组和对照组比较,既往房屋倒塌情况、家庭成员在地震中死亡情况、地震后农药的污染情况在两组比较中差异具有统计学意义(均P<0.01)。结论:唐山地区地震后当地乳腺癌的发病特点有所变化,采用合理的预防措施,可降低乳腺癌发病率,对其他震后地区有借鉴意义。
Objective: Breast cancer is a common malignant tumor in women. There are many unique risk factors for the development of breast cancer after the Tangshan earthquake, and the characteristics of its occurrence have changed. Methods: From July 2006 to July 2011, 800 newly diagnosed breast cancer patients from Tangshan Workers Hospital, Tangshan Women and Children Hospital, Tangshan People’s Hospital and Hebei United University Hospital were selected as study groups. The control group consisted of 800 patients with non-malignant tumors, non-endocrine system and non-reproductive system diseases admitted to the above hospitals, and the daily exposure between the two groups was consistent. All subjects experienced the Tangshan earthquake and have been living in the area. Logistic regression model was used to analyze the relationship between various risk factors and the etiology of breast cancer. Results: Compared with the control group, the collapse of the former houses, the death of the family members in the earthquake and the pollution of pesticides after the earthquake in the two groups were significantly different (all P <0.01). Conclusion: The incidence of local breast cancer in Tangshan area has changed after the earthquake. Reasonable preventive measures can reduce the incidence of breast cancer and provide reference for other post-earthquake areas.