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近年来的研究认为细胞外谷氨酸浓度的增加是导致缺血性神经损害的主要因素。这一观念主要基于对动物试验的研究结果。闭塞小动物的双侧颈动脉可导致细胞外谷氨酸浓度增高7～10倍。谷氨酸受体拮抗剂也已在急性卒中病人中进行临床试验。但有关正常人或缺血人或缺血人脑细胞外谷氨酸及其他氨基酸水平的资料却很少。本文作者采用在体微透析做为监测手段,对人脑颞叶缺血模型细胞外液中七种氨基酸(谷氨酸、丝氨酸、谷氨酰胺、甘氨酸、牛黄酸、丙氨酸和r—氨络酸)的浓度进行研究。
In recent years, studies suggest that the increase of extracellular glutamate concentration is the main factor leading to ischemic nerve damage. This notion is based primarily on the findings of animal experiments. Occlusion of small animals bilateral carotid artery lead to extracellular glutamate concentration increased 7 to 10 times. Glutamate receptor antagonists have also been tested in acute stroke patients. However, there are few data on extracellular extracellular glutamate and other amino acids in normal or ischemic human or ischemic brain. In this study, we used in-vivo microdialysis as a monitoring tool to detect seven amino acids (glutamic acid, serine, glutamine, glycine, taurine, alanine and r- ammonia Acid) concentration of the study.