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目的探讨矽肺和矽肺结核患者体内是否存在Th1/Th2失衡。方法选择69名矽肺和矽肺结核患者作为研究对象,另以24名健康人为对照,使用酶联免疫吸附试验对血清白细胞介素(IL)-4、IL-10以及肿瘤坏死因子-α(TNF-α)进行检测和统计分析。结果矽肺和矽肺结核组血清TNF-α低于对照组,而血清IL-10和IL-4明显高于健康对照组。矽肺、矽肺结核组IL-4、IL-10以及TNF-α与健康对照组比较差异有显著性(P<0.05或P<0.01)。结论矽肺和矽肺结核患者机体细胞免疫功能低下,存在Th1反应减弱,Th2反应增强。
Objective To investigate the existence of Th1 / Th2 imbalance in silicosis and silicosis patients. Methods Sixty-nine patients with silicosis and silicotic pulmonary tuberculosis were enrolled in this study. Twenty-four healthy controls were used as controls. Serum interleukin (IL) -4, IL-10 and tumor necrosis factor-α (TNF- α) for detection and statistical analysis. Results Serum levels of TNF-α in silicotic and silicotic TB patients were lower than those in control group, while serum levels of IL-10 and IL-4 in serum were significantly higher than those in healthy controls. The levels of IL-4, IL-10 and TNF-α in silicosis group and silicotic pulmonary tuberculosis group were significantly different from those in healthy control group (P <0.05 or P <0.01). Conclusion The patients with silicotic and silicotic tuberculosis have poor cellular immune function, which results in weakened Th1 response and enhanced Th2 response.