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复杂疾病的产生是多种分离的遗传变异和环境因素相互作用的结果。遗传变异的产生原因是突变,而它在群体中的频率变化,则主要地决定于随机遗传漂变和来自环境的自然选择。人类的进化和迁徙历程,总是伴随着在不断变化的外界环境选择下的适应,而这种选择与适应,已深刻地影响着人类基因组结构的多态性。对疾病的遗传分析,不仅需要从横向的空间上分析不同群体或个体的遗传变异对疾病谱和易感性的影响,而且需要在纵向的进化史中,把环境暴露相关疾病的自然史和人类的分子适应性进化结合起来,考察人类起源迁移的群体历史中,动态变化的环境风险
The production of complex diseases is the result of the interaction between multiple isolated genetic variations and environmental factors. The cause of genetic variation is mutation, and its frequency change in the population is mainly determined by random genetic drift and natural selection from the environment. The course of human evolution and migration is always accompanied by the adaptation under the changing external environment choice. Such choice and adaptation have profoundly influenced the polymorphism of human genome structure. Genetic analysis of diseases not only requires a horizontal and spatial analysis of the impact of genetic variation of different groups or individuals on disease spectrum and susceptibility, but also the need to address the natural history of environmental exposure-related diseases in humans and human Molecular adaptive evolution combined to examine the history of human migration in the population, the dynamic environmental risk changes