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目的观察血必净注射液对慢性肺心病急性期患者肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的影响。方法将90例慢性肺心病急性期患者随机分成对照组与观察组。对照组45例,予吸氧、抗感染、平喘、祛痰、利尿、强心等西医常规综合治疗;观察组45例,在西医常规综合治疗基础上予血必净注射液50 ml加入生理盐水100 ml,静脉滴注,2次/日,共用7 d。两组患者于治疗前、治疗后第7 d抽取外周血,采用化学发光法检测血清TNF-α、IL-6。结果治疗后两组患者TNF-α、IL-6均显著低于治疗前(p<0.05),观察组又显著低于对照组(p<0.05)。结论血必净注射液能够降低慢性肺心病急性期患者外周血中TNF-α、IL-6水平。
Objective To observe the effects of Xuebijing Injection on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with chronic pulmonary heart disease. Methods 90 patients with chronic pulmonary heart disease were randomly divided into control group and observation group. In the control group, 45 cases were given conventional therapy such as oxygen inhalation, anti-infective, antiasthmatic, expectorant, diuretic and cardiac therapy. In the observation group, 45 cases were treated with 50 ml Xuebijing Injection 50 ml Saline 100 ml, intravenous infusion, 2 times / day, sharing 7 d. Peripheral blood was taken before treatment and on the 7th day after treatment in both groups, and the levels of serum TNF-α and IL-6 were detected by chemiluminescence. Results After treatment, the levels of TNF-α and IL-6 in both groups were significantly lower than those before treatment (p <0.05), and significantly lower than those in the control group (p <0.05). Conclusion Xuebijing Injection can reduce the level of TNF-α and IL-6 in peripheral blood of patients with chronic pulmonary heart disease.