AIM:To investigate the levels of D-dimer(DD)and yonWillebrand factor(vWF)and the relationship between DDand vWF in ulcerative colitis(UC)patients.METHODS:A total of 29 plasma specimens were obtainedfrom patients with ulcerative colitis(male 13,female 16),aged 21-47 years(33±11).Disease activity was assessed byTruelove Writeria.Patients with a score of above 5 wereregarded as having active colitis.Twenty healthy people(male 12,female 8),aged 19-53 years(31±14),served asnormal controls.Blood samples were taken from anantecubital vein puncture.Blood(1.8 mL)was injected intothe tubes containing sodium citrate(0.13 mmol/L).Theplasma was obtained by centrifugation at 3000 r·min~(-1)for 10min,and stored at-80℃ until assayed by ELISA.RESULTS:The mean plasma levels of DD and vWF in activeUC patients were significantly higher than those of thecontrols(0.69±0.41 vs0.27±0.11,P<0.01;143±46 vs103±35,P<0.01).The mean plasma levels of DD in thepatients with active disease were higher than those withinactive disease(0.69±0.41 vs 0.48±0.29,P<0.05).Thelevels of vWF were not different between active and inactivepatients.DD levels were positively related to vWF levels(r=0.574,P<0.01).There was no significant differencebetween levels of DD and vWF and the scope of disease andsex of the patients.CONCLUSION:vWF is an important feature and a goodmarker of UC;intravascular thrombus and endothelial celldysfunction were found in UC patients;and the combinedtest of DD and vWF is helpful to distinguish the activity ofthe UC patients. AIM: To investigate the levels of D-dimer (DD) and yonWillebrand factor (vWF) and the relationship between DD and vWF in ulcerative colitis (UC) patients. METHODS: A total of 29 plasma specimens were obtained from patients with ulcerative colitis , female 16), aged 21-47 years (33 ± 11) .Disease activity was assessed byTruelove Writer.Patients with a score of above 5 wereregarded as having active colitis.Twenty healthy people (male 12, female 8), aged 19- The samples were taken from an antecubital vein puncture. Blood (1.8 mL) was injected intothe tubes containing sodium citrate (0.13 mmol / L). Theplasma was obtained by centrifugation at 3000 r · min ~ (-1) for 10 min, and stored at -80 ° C until assayed by ELISA .RESULTS: The mean plasma levels of DD and vWF in active UC patients were significantly higher than those of the control (0.69 ± 0.41 vs 0.27 ± 0.11, P <0.01; 143 ± 46 vs 103 ± 35, P <0.01). The mean plasma levels of DD in the patients with active disease were higher than tho (0.69 ± 0.41 vs 0.48 ± 0.29, P <0.05). The levels of vWF were not different between active and inactive patients. DD levels were positively related to vWF levels (r = 0.574, P <0.01) difference between levels of DD and vWF and the scope of disease and sex of the patients. CONCLUSION: vWF is an important feature and a good marker of UC; intravascular thrombus and endothelial cell function were found in UC patients; and the combined test of DD and vWF is helpful to distinguish the activity of the UC patients.